JMJD1C Polyclonal Antibody
货号：PA5-63258
规格：100 µL
价格：5942
产品类型：标签抗体
品牌：Thermo Fisher
抗原：Recombinant protein corresponding to Human JMJD1C
物种：人
宿主：兔
抗体亚型：IgG
荧光染料：其它
| 类型: | 一抗 | 同型对照： | |
| 浓度： | 0.2 mg/mL | 用法： | 0.25-2 µg/mL(ICC)；0.25-2 µg/mL（IF）；1:200-1:500（IHC） |
产品详细信息Immunogen sequence: PNVSDSKHSI ANAKFLETAK KDSDQSWVSD VVKVDLTQSS VTNASSGNDH LNMEKEKYVS YISPLSAVSV MEDKLHKRSP PPETIKSKLN TSVDTHKIKS SPSPEVVKPKHighest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 77%.靶标信息The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.
| 数据： |
JMJD1C Antibody (PA5-63258) in IFImmunofluorescent staining of JMJD1C in human cell line U-2 OS using a JMJD1C Polyclonal Antibody (Product # PA5-63258) shows localization to nucleus and cytosol. JMJD1C Antibody (PA5-63258) in IHCImmunohistochemical staining of JMJD1C in human testis using a JMJD1C Polyclonal Antibody (Product # PA5-63258) shows moderate nuclear positivity in cells in seminiferous duct. |
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