Phospho-BRCA1 (Ser1387) Polyclonal Antibody

货号：PA5-105931

规格：100 µL

价格：4711

产品类型：标签抗体

品牌：Thermo Fisher

抗原：A synthesized peptide derived from human BRCA1 aro

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:50-1:200(IHC(P));1:1000-1:3000(WB)

靶标信息BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

数据：

Phospho-BRCA1 (Ser1387) Antibody (PA5-105931) in IHC (P)Immunohistochemistry analysis of paraffin-embedded Phospho-BRCA1 (Ser1387) in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-BRCA1 (Ser1387) polyclonal antibody (Product # PA5-105931) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit. Phospho-BRCA1 (Ser1387) Antibody (PA5-105931) in WBWestern blot analysis of Phospho-BRCA1 (Ser1387) in EGF treated A431 cell lysate (absence (-) or presence (+) of non-phospho and phospho peptide). Samples were incubated with Phospho-BRCA1 (Ser1387) polyclonal antibody (Product # PA5-105931).

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