FALZ Polyclonal Antibody

货号：PA5-83057

规格：100 µL

价格：6049

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant protein corresponding to Human BPTF

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.2mg/mL	用法：	0.25-2 µg/mL（ICC）；0.25-2 µg/mL(IF);1:50-1:200(IHC(P)）

产品详细信息Immunogen sequence: SKLSQLKSQQ VAAAAHEANK LFKEGKEVLV VNSQGEISRL STKKEVIMKG NINNYFKLGQ EGKYRVYHNQ YSTNSFALNK HQHREDHDKR RHLAHKFCLT PAGEFKWNGS VHGSKVLTIS TLRLTITQL靶标信息BPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease. Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).Tissue specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).

数据：

FALZ Antibody (PA5-83057) in IFImmunofluorescent analysis of FALZ in A-431 cells using a FALZ polyclonal antibody (Product # PA5-83057). The analysis shows localization to nucleoplasm. FALZ Antibody (PA5-83057) in IHCImmunohistochemical analysis of FALZ in human adrenal gland using a FALZ polyclonal antibody (Product # PA5-83057). The analysis shows moderate cytoplasmic positivity in glandular cells.

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