Mouse CD27 ELISA Kit ELISA试剂盒,Mouse CD27 ELISA Kit/小鼠CD27 ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse CD27 ELISA Kit ELISA试剂盒,Mouse CD27 ELISA Kit/小鼠CD27 ELISA试剂盒

2024-10-24

Mouse CD27 ELISA Kit/小鼠CD27 ELISA试剂盒

货号：EM13RB,EM13RBX5,EM13RBX10

规格：96 Tests,5X96 Tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：小鼠

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	32 pg/mL
检测范围	32-8,000 pg/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	CD27
Protein aliases	CD antigen 27, CD27, CD27 antigen, CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, tumor necrosis factor receptor superfamily, member 7
物种（Tested）	小鼠
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	Cd27, S152, Tnfrsf7, Tp55
Gene ID	(Mouse) 21940
Gene symbol	Cd27
UniProt ID	(Mouse) P41272

Mouse CD27 quantitates mouse CD27 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse CD27.小鼠CD27定量分析血清，血浆，上清液中的小鼠CD27。该检测试剂盒将专门识别天然和重组小鼠CD27。Target information 靶标信息CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.CD27是肿瘤坏死因子（TNF）受体超家族的50 kDa成员，包括CD40和CD30。 TNF超家族成员以调节细胞增殖和死亡而闻名。与其他TNFR / TNF家族成员的表达相反，CD27及其配体CD70的表达主要局限于淋巴细胞。 CD27的高表达水平似乎取决于抗原受体的正确连接。 CD70表达需要其他共刺激和/或促炎信号。 CD27在成熟胸腺细胞，外周血T细胞和B细胞亚群上以二硫键连接的同型二聚体表达。通过TCR-CD3复合物激活T细胞会导致CD27在质膜上的表达上调，并释放在血浆，尿液或脊髓液中检测到的可溶性28-32 kDa形式sCD27。可溶性CD27是急性和慢性B细胞恶性肿瘤的重要预后指标。 RgpA，一种半胱氨酸蛋白酶，尽管通过蛋白酶激活的受体（PARs）激活T细胞，但会降解CD27并抵消CD27及其配体CD70介导的T细胞激活。 CD27结合蛋白（SIVA）是一种促凋亡蛋白，可以与该受体结合，并被认为在该受体诱导的凋亡中起重要作用。与CD27功能障碍相关的疾病包括淋巴组织增生综合征2和常染色体隐性隐匿性淋巴组织增生综合征。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Mouse CD27 ELISA Kit ELISA试剂盒,Mouse CD27 ELISA Kit/小鼠CD27 ELISA试剂盒

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