MPP8 Polyclonal Antibody

货号：PA5-58891

规格：100 µL

价格：5548

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant protein corresponding to Human MPP8

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.1 mg/mL	用法：	1:500-1:1000（IHC）；0.25-2 µg/mL（ICC）；0.25-2 µg/mL(IF);0.04-0.4 µg/mL(WB）

产品详细信息Immunogen sequence: GLEHGFEKPL DSAMSAEEDT DVRGRRKKKT PRKAEDTREN RKLENKNAFL EKKTVPKKQR NQDRSKSAAE LEKLMPVSAQ TPKGRRLSGE ERGLWSTDSA EEDKETKRNE SKEHighest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 58%.靶标信息Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 (PubMed:26022416, PubMed:28581500). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592). Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). [UniProt]

数据：

MPP8 Antibody (PA5-58891) in IFImmunofluorescent staining of MPP8 in human cell line U-2 OS shows positivity in nucleus, nucleoli and plasma membrane. Samples were probed using a MPP8 Polyclonal Antibody (Product # PA5-58891). MPP8 Antibody (PA5-58891) in IHCImmunohistochemical staining of MPP8 in human testis using a MPP8 Polyclonal Antibody (Product # PA5-58891) shows strong nuclear positivity in cells in seminiferous ducts and Leydig cells.

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