Mouse Leptin R ELISA Kit ELISA试剂盒,Mouse Leptin R ELISA Kit/小鼠瘦素R ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Mouse Leptin R ELISA Kit ELISA试剂盒,Mouse Leptin R ELISA Kit/小鼠瘦素R ELISA试剂盒

2024-10-24

Mouse Leptin R ELISA Kit/小鼠瘦素R ELISA试剂盒

货号：EM48RB,EM48RBX5,EM48RBX10

规格：96 Tests,5X96 Tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：小鼠

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	32 pg/mL
检测范围	32-8,000 pg/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	Leptin Receptor
Protein aliases	B219, CD295, LEP-R, Leptin receptor, leptin receptor gene-related protein, OB receptor, OB-R
物种（Tested）	小鼠
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	Db, diabetes, Lepr, Leprb, LEPROT, Modb1, OB-RGRP, obese-like, obl, Obr
Gene ID	(Mouse) 16847
Gene symbol	Lepr
UniProt ID	(Mouse) P48356

Mouse Leptin R quantitates mouse Leptin R in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse Leptin R.小鼠瘦素R定量分析血清，血浆，上清液中的小鼠瘦素R。该检测试剂盒将专门识别天然和重组小鼠瘦蛋白R。Target information 靶标信息The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.瘦素（OB-R）受体是细胞因子受体超家族的成员，该家族在哺乳动物体重稳态和能量平衡中起重要作用。脂肪组织分泌的激素瘦素对配体诱导的OB-R激活似乎通过Janus激酶（JAK）/信号转导子和转录激活子（STAT）途径激活下游信号转导事件。瘦蛋白可以使OB-R胞外域同源二聚体，而下游信号转导事件是由OB-R胞内域的同源二聚体引发的。 OB-R的几种同工型在长度和信号传递能力上有所不同。已经在脉络丛和下丘脑中发现了编码OB-R长形式的RNA转录物，已提出将其作为饱腹感和能量消耗的控制中心。小鼠OB-R（db）或瘦素（ob）基因中的突变已显示可导致早发性肥胖。可归因于这些基因型的代谢异常包括高皮质激素血症，高胰岛素血症和胰岛素抵抗，高血糖症，中枢神经系统活性改变，褐色脂肪组织的代谢率降低以及白色脂肪组织的大量增加。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Mouse Leptin R ELISA Kit ELISA试剂盒,Mouse Leptin R ELISA Kit/小鼠瘦素R ELISA试剂盒

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