CD71 (Transferrin Receptor) Monoclonal Antibody (OKT9 (OKT-9)), Functional Grade, eBioscience™/CD71 (Transferrin Receptor) 单克隆抗体(OKT9 (OKT-9)), 功能抗体

货号：16-0719-81,16-0719-85,16-0719-38

规格：50 µg,500 µg,5 mg

价格：1283,3847,24089

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

荧光染料：Alexa Fluor 488

类型:	一抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	0.5µg/test（Flow）

产品详细信息Description: The OKT9 monoclonal antibody reacts with human CD71, a 170-180 kDa type II transmembrane protein. CD71, the transferrin receptor, exists as a homodimer on the cell surface and is essential for cellular growth. CD71 is expressed by immature proliferating cells and at low levels on resting mature lymphocytes. Antigen or mitogen stimulation of T and B cells upregulates the expression of CD71.Applications Reported: This OKT9 (OKT-9) antibody has been reported for use in flow cytometric analysis.Applications Tested: This OKT9 (OKT-9) antibody has been tested by flow cytometric analysis of PHA-stimulated human peripheral blood mononuclear cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means ofdetecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.仅用于科研。不用于诊断过程。未经明确授权不得转售。

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参考文献：

1.Nature communicationsGenetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin."Published figure using CD71 (Transferrin Receptor) monoclonal antibody (Product # 16-0719-81) in Flow Cytometry"2.Stem cells translational medicineEnforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells."Published figure using CD71 (Transferrin Receptor) monoclonal antibody (Product # 16-0719-81) in Flow Cytometry"3.Cell stem cellTargeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells."Published figure using CD71 (Transferrin Receptor) monoclonal antibody (Product # 16-0719-81) in Flow Cytometry" 4.Proceedings of the National Academy of Sciences of the United States of AmericaAdenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation."16-0719 was used in Flow cytometry/Cell sorting to indicate that Ad35 may use CD46 because engagement induces CD46 down-regulation and preferentially suppresses naive CD4+ T-cell activation."AuthorsAdams WC,Gujer C,McInerney G,Gall JG,Petrovas C,Karlsson Hedestam GB,Koup RA,Loré K

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