TNF alpha Monoclonal Antibody (MAb1), Functional Grade, eBioscience™/TNF alpha 单克隆抗体 (MAb1), 功能抗体

货号：16-7348-81,16-7348-85

规格：50 µg,500 µg

价格：1091,3274

产品类型：流式抗体

品牌：eBioscience

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

荧光染料：其它

类型:	一抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：

产品详细信息Description: The MAb1 antibody reacts with human tumor necrosis factor-alpha (TNF-alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4^+ T cells. TNF-alpha has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF-alpha forms dimers and trimers and also exists as a 26 kDa membrane bound form.Applications Reported: The Mab1 antibody has been reported for use in ELISA, ELISPOT, intracellular staining and neutralization.Applications Tested: The MAb1 antibody has been tested for neutralizing TNF alpha binding and biological activity.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.仅用于科研。不用于诊断过程。未经明确授权不得转售。

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参考文献：

1.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsTh17 Responses to Collagen Type V, kα1-Tubulin, and Vimentin Are Present Early in Human Development and Persist Throughout Life."16-7348 was used in Functional assays to investigate the basis of the T helper 17-dependent autoimmune responses associated with fibro-obliterative forms of chronic rejection following heart or lung transplantation."2.International journal of molecular medicineIL-1β impedes the chondrogenic differentiation of synovial fluid mesenchymal stem cells in the human temporomandibular joint."16-7348 was used in Functional assays to indicate the potential adverse effects of IL-1β on the chondrogenic differentiation of SFMSCs, which may provide new insight into the pathogenesis of TMD."AuthorsLiu W,Sun Y,He Y,Zhang H,Zheng Y,Yao Y,Zhang Z3.mAbsRecombinant H22(scFv) blocks CD64 and prevents the capture of anti-TNF monoclonal antibody. A potential strategy to enhance anti-TNF therapy."16-7348 was used in Functional assays to demonstrate the specific blocking of CD64 by H22(scFv) could be used as a mechanism for potentiating the effect of anti-TNF antibodies."AuthorsHristodorov D,Mladenov R,Brehm H,Fischer R,Barth S,Thepen T

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