Thermo CD103 (Integrin alpha E) Monoclonal Antibody (2E7), FITC,CD103 (Integrin alpha E) Monoclonal Antibody (2E7), FITC-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Thermo CD103 (Integrin alpha E) Monoclonal Antibody (2E7), FITC,CD103 (Integrin alpha E) Monoclonal Antibody (2E7), FITC

2024-10-24

CD103 (Integrin alpha E) Monoclonal Antibody (2E7), FITC

货号：11-1031-81,11-1031-82,11-1031-85

规格：50μg,100μg,500μg

价格：934,1752,3360

产品类型：流式抗体

品牌：Thermo Fisher

物种：小鼠

宿主：仓鼠

抗体亚型：IgG

荧光染料：FITC

抗体类型	单抗	同型对照：	Armenian Hamster IgG Isotype Control (eBio299Arm), FITC
浓度：	0.5 mg/mL	用法：	1 μg/test (Flow)
产品详细信息Description: The 2E7 monoclonal antibody reacts with mouse CD103, the alphaE integrin. CD103 non-covalently associates with integrin beta7 and is expressed on all intraepithelial lymphocytes, a small subset of peripheral lymphocytes, and dendritic epidermal T cells (DEC). Epithelial cell antigen E-cadherin binds to CD103 and mediates homing of lymphocytes to the intestinal epithelium.Applications Reported: The 2E7 antibody has been reported for use in flow cytometric analysis.Applications Tested: The 2E7 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells. In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain. CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. CD103 is part of the integrin family which are heterodimeric integral membrane proteinscomposed of an alpha chain and a beta chain. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
数据
CD103 (Integrin alpha E) Antibody (11-1031-82) in FlowStaining of C57Bl/6 lymph node cells with Anti-Mouse CD3e APC (Product # 17-0031-82) and 1.0 µg of Armenian Hamster IgG Isotype Control FITC (Product # 11-4888-81) (left) or 1.0 µg of Anti-Mouse CD103 (Integrin alpha E) FITC (right). Cells in the lymphocyte gate were used for analysis.
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参考文献：
1.Protein and cellContact-dependent delivery of IL-2 by dendritic cells to CD4 T cells in the contraction phase promotes their long-term survival."Published figure using CD103 (Integrin alpha E) monoclonal antibody (Product # 11-1031-82) in Flow Cytometry"2.Nature communicationsVirus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy."Published figure using CD103 (Integrin alpha E) monoclonal antibody (Product # 11-1031-82) in Flow Cytometry"3.Journal of neuroinflammationCSF1R antagonism limits local restimulation of antiviral CD8+T cells during viral encephalitis."Published figure using CD103 (Integrin alpha E) monoclonal antibody (Product # 11-1031-82) in Flow Cytometry"4.Investigative ophthalmology and visual scienceBilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland."11-1031 was used in Flow cytometry/Cell sorting to demonstrate that a unilateral cut of the corneal nerve results in activation of immune cells on the ocular surface and dysregulation of lacrimal secretion bilaterally through the bidirectional neuronal signals."AuthorsLee HK,Kim KW,Ryu JS,Jeong HJ,Lee SM,Kim MK5.The EMBO journalDeletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice."Published figure using CD103 (Integrin alpha E) monoclonal antibody (Product # 11-1031-82) in Flow Cytometry"

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Thermo CD103 (Integrin alpha E) Monoclonal Antibody (2E7), FITC,CD103 (Integrin alpha E) Monoclonal Antibody (2E7), FITC

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