Rabbit anti Human presenilin-1 antibody 伯乐 VPA00332 presenilin-1抗体-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti Human presenilin-1 antibody 伯乐 VPA00332 presenilin-1抗体

2024-10-28

Rabbit anti Human presenilin-1 antibody

货号：VPA00332

规格：100 uL

市场价格：2890

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：presenilin-1

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti Human presenilin-1 antibodyrecognizes presenilin-1 also known as PSEN1.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (presenilin-1 or presenilin-2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for Presenilin-1, the full-length nature of only some have been determined (provided by RefSeq, Aug 2008).Rabbit anti Human presenilin-1 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
产品详情
Target Species	Human
Product Form	Ig fraction - liquid
Preparation	Rabbit Ig fraction prepared by ammonium sulphate precipitation.
Buffer Solution	Phosphate buffered saline.
Preservative Stabilisers	0.09% Sodium Azide (NaN3).
Immunogen	KLH-conjugated synthetic peptide corresponding to aa 330-359 of human presenilin-1
Acknowledgements	PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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技术参数

产品应用 WB

产品类型 PrecisionAb Polyclonal

推荐用于 WB

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Rabbit anti Human presenilin-1 antibody 伯乐 VPA00332 presenilin-1抗体

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