mouse anti human C5 伯乐 mouse anti human C5 MCA2610-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

mouse anti human C5 伯乐 mouse anti human C5 MCA2610

2024-10-29

mouse anti human C5

货号：MCA2610

规格：0.1 mg

市场价格：5253

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：C5

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：046-10.2.2 (10-04)

荧光染料：Purified

产品介绍
Mouse anti Human C5 antibody, clone 046-10.2.2recognizes secreted complement component 5 (C5), a ~190 kDa serine protease present in blood serum. It is composed of an ~115 kDa disulphide linked alpha-chain and a ~75 kDa beta-chain. In addition to its role in complement, C5 is thought to be associated with inflammation, stimulating tumour necrosis factor alpha, interferon gamma mediated suppression of IL-10 and IL-12 production.C5 is activated via either the classical or the alternative complement pathway, by proteolytic cleavage of C5a from the N-terminal of the alpha-chain, by C5 convertase. C5a is an anaphylotoxin which mediates local inflammation. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. It also stimulates chemotaxis of neutrophils, eosinophils, basophils and monocytes towards the site of inflammation. The remaining fragment, C5b, initiates the assembly of the membrane attack complex.Mouse anti Human C5 antibody, clone 046-10.2.2 blocks C5 haemolytic activity (Harderet al.2017).Removal of sodium azide is recommended prior to use in functional assays.
产品详情
Target Species	Human
Product Form	Purified Ig - liquid
Preparation	Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution	Borate buffered saline
Immunogen	Purified human C5.
Approx. Protein Concentrations	Current, batch-specific concentration 1.08 mg/ml
Preservative Stabilisers	0.1% Sodium Azide (NaN3)
Regulatory	For research purposes only
Guarantee	Guaranteed until date of expiry. Please see product label.
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light.
应用
Application Name	Verified	Min Dilution	Max Dilution
ELISA	√
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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文献
1.Karp, C.L.et al.(2000) Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma.Nat Immunol. 1 (3): 221-6.2.Peng, T.et al.(2005) Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response.J Clin Invest. 115 (6): 1590-600.

技术参数

产品应用 ELISA;FN;WB

产品类型单克隆抗体

推荐用于 ELISA;FN;WB

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mouse anti human C5 伯乐 mouse anti human C5 MCA2610

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