Rabbit anti RelB (pSer573) antibody bio-rad,Rabbit anti RelB (pSer573) antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti RelB (pSer573) antibody bio-rad,Rabbit anti RelB (pSer573) antibody

2024-10-22

Rabbit anti RelB (pSer573) antibody

货号：AHP2675

规格：50 µl

价格：3570

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：RelB (pSer573)

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti RelB (pSer573) antibodyrecognizes the transcription factor RelB, also known as I-Rel, when phosphorylated at serine 573. RelB is encoded by the v-rel avian reticuloendotheliosis viral oncogene homolog B gene and is a critical component of the NF-kappa-B pathway.Upon cleavage of the NF-kappa-B p105 and p100 subunits into the NF-kappa-B p50 and p52 subunits, RelB forms RelB-p50 and RelB-p52 heterodimers. These dimers act as activators of transcription by binding to kappaB sites present on DNA (Oeckinghaus and Ghosh 2009). RelB-p50 and RelB-p52 binding induces the expression of genes mediating immune responses, inflammation and apoptosis (Jing and Lee 2014).NF-kappa-B pathway has been implicated in a variety of disease states including autoimmunity and cancer. As the NF-kappa-B pathway has been demonstrated to be constitutively active in a large group of tumors and therefore developing NF-kappa-B inhibitors has emerged as a new cancer therapy approach (Chaturverdiet al. 2011,Baud and Karinet al. 2009). RelB is phosphorylated at serine 573 leading to degradation (Marienfeld et al. 2001)
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antiserum to RelB (pSer573) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02% Sodium Azide50% Glycerol
Immunogen	Phospho specific-peptide corresponding to residues surrounding serine 573 of human RelB
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
Store at -20℃Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
Western Blotting	√	1/500	1/2000
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C,E,WB	1mg
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E,WB	1mg
文献
1.Oeckinghaus, A. & Ghosh, S. (2009) The NF-kappaB family of transcription factors and its regulation.Cold Spring Harb Perspect Biol. 1 (4): a000034.2.Jing, H. & Lee, S. (2014) NF-κB in cellular senescence and cancer treatment.Mol Cells. 37 (3): 189-95.3.Chaturvedi, M.M.et al.(2011) NF-κB addiction and its role in cancer: 'one size does not fit all'.Oncogene. 30 (14): 1615-30.4.Baud, V. & Karin, M. (2009) Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.Nat Rev Drug Discov. 8 (1): 33-40.5.Marienfeld, R.et al.(2001) Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-kappaB control.Oncogene. 20 (56): 8142-7.

技术参数

产品应用 wb

产品类型 Polyclonal Antibody

推荐用于 wb

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Rabbit anti RelB (pSer573) antibody bio-rad,Rabbit anti RelB (pSer573) antibody

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