Rabbit anti SIGIRR (C-terminal) antibody AHP1784 bio-rad,Rabbit anti SIGIRR (C-terminal) antibody-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Rabbit anti SIGIRR (C-terminal) antibody AHP1784 bio-rad,Rabbit anti SIGIRR (C-terminal) antibody

2024-10-22

Rabbit anti SIGIRR (C-terminal) antibody

货号：AHP1784,AHP1784T

规格：0.1 mg,50 µg

价格：4573,2482

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：SIGIRR (C-terminal)

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：Purified

产品介绍
Rabbit anti SIGIRR (C-terminal) antibodyrecognizes the Single Ig IL-1-related receptor, also known as SIGIRR, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8 or TIR8. SIGIRR is a 409 amino acid ~ 45-90 kDa single pass type III transmembrane glycoprotein, Multiple species of SIGIRR seen in western blotting are achieved through differential glycosylation at four potential glycosylation sites in the SIGIRR ectodomain, mutation at these sites to eliminate glycosylation yields a single band of the predicted size (44 kDa) for unmodified SIGIRR (Zhaoet al.2015).SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily, defined by an intracellular Toll-IL-1R (TIR) domain. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signalling pathways. It interacts with TLR4, TLR5, TLR9 and IL-1R through the extracellular Ig domain, or the intracellular TIR domain. The Ig domain interferes with the heterodimerization of IL-1R while the intracellular TIR domain inhibits both IL-1 and LPS signalling by attenuating the recruitment of receptor-proximal signalling components to TLR4. SIGIRR is expressed in kidney, colon, small intestine, lung, spleen and liver. It is not expressed in brain or muscle.Rabbit anti SIGIRR antibody has been successfully used for the detection of SIGIRR in both murine and human samples by western blotting (Zhaoet al.2015)
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Species Cross-Reactivity	Target Species	Cross Reactivity
Mouse	√
N.B. Antibody reactivity and working conditions may vary between species.
Antiserum Preparation	Antiserum to SIGIRR (CT) was raised by repeated immunisation of with highly purified antigen. Purified IgG was prepared from whole serum by immunoaffinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	0.02% Sodium Azide (NaN3)
Immunogen	A synthetic peptide corresponding to 15 amino acids near the carboxy terminus of mouse SIGIRR.
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Frozen	√		10ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
二抗
Description	Product Code	Applications	Pack Size
Goat anti Rabbit IgG (Fc):Biotin	STAR121B	E,WB	1mg
Goat anti Rabbit IgG (H/L):HRP	STAR124P	C,E,WB	1mg

技术参数

产品应用 wb

产品类型 Polyclonal Antibody

推荐用于 wb

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Rabbit anti SIGIRR (C-terminal) antibody AHP1784 bio-rad,Rabbit anti SIGIRR (C-terminal) antibody

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