Bio-Rad AHP1827Z LAT1,Rabbit anti Human LAT1:Preservative Free-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Bio-Rad AHP1827Z LAT1,Rabbit anti Human LAT1:Preservative Free

2024-10-22

Rabbit anti Human LAT1:Preservative Free

货号：AHP1827Z

规格：0.1 mg

价格：3443

产品类型：免疫组化一抗

品牌：Bio-Rad

抗原：LAT1

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Preservative Free

产品介绍
Rabbit anti Human LAT1 antibodyrecognizes human LAT1 (L-type amino acid transporter 1), a heterodimeric Na+-independent amino acid transporter protein and member of the amino acid-polyamine-organocation (APC) superfamily, involved in the high-affinity transport of large neutral amino acids, in association with SLC3A2/4F2hc.LAT1 is highly expressed in the brain and is involved in the transport of L-DOPA across the blood-brain barrier, in brain neurogenesis, and acts as a mediator of L-leucine transport across the inner blood-retinal barrier. LAT1 is involved in the cell membrane transport of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in the placenta, and is the foremost transporter of tyrosine in fibroblasts.
产品详情
Target Species	Human
Product Form	Purified IgG - liquid
Antiserum Preparation	Antiserum to human Lat1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution	Phosphate buffered saline
Preservative Stabilisers	None present
Approx. Protein Concentrations	IgG concentration 1.0 mg/ml
Immunogen	Keyhole limpet haemocyanin (KLH) conjugated synthetic peptide C-RHRKPEL, representing an internal portion of human LAT1 located towards the C-terminus (aa. 419-425).
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
存储条件
Store at -20℃only.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Paraffin	√	5ug/ml
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Histology Positive Control Tissue Breast
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文献
1. Fraga, S.et al.(2005) Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells.Amino Acids. 29 (3): 229-33.2. Soares-da-silva, P.et al.(2005) Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK.Acta Physiol Scand. 185 (1): 71-8.3. Pinho, M.J.et al.(2011) LAT1 overexpression and function compensates downregulation of ASCT2 in anin vitromodel of renal proximal tubule cell ageing.Mol Cell Biochem. 349 (1-2): 107-16.

技术参数

产品应用 IHC(P)

产品类型 Polyclonal Antibody

推荐用于 IHC(P)

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Bio-Rad AHP1827Z LAT1,Rabbit anti Human LAT1:Preservative Free

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