IL-6 Monoclonal Antibody (I6YOR5/66), eBioscience/IL-6单克隆抗体(I6YOR5 / 66)
货号:BMS130-2
规格:100 µg
价格:2926
产品类型:抗体和ELISA
品牌:eBioscience
类型: | 单抗 | 同型对照: | |
浓度: | 1 mg/mL | 用法: | Assay-Dependent(ELISA) |
产品详细信息BMS130-2 specifically recognizes human IL-6.Purity is > 95% IgG2a as determined by SDS-gel electrophoresis. Endotoxin: <0.5 EU/µg靶标信息Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloidprogenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.
数据: |
IL-6 Antibody (BMS130-2)The Journal of biological chemistry 2010 -Published figure using IL-6 monoclonal antibody (Product # BMS130-2) |
参考文献: |
1. The Journal of biological chemistryLoss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa. |
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