Human CLEC9A ELISA Kit ELISA试剂盒,Human CLEC9A ELISA Kit/人CLEC9A ELISA试剂盒-试剂- bio-rad伯乐一级代理 |伯乐Aminex |伯乐电泳槽1658001| 伯乐ddPCR bio-rad授权代理商、biorad伯乐qpcr仪

Human CLEC9A ELISA Kit ELISA试剂盒,Human CLEC9A ELISA Kit/人CLEC9A ELISA试剂盒

2024-10-23

Human CLEC9A ELISA Kit/人CLEC9A ELISA试剂盒

货号：EH111RB,EH111RBX5,EH111RBX10

规格：96 tests,5X96 tests,10X96 tests

价格：6641,29884,57271

产品类型：Platinum ELISA

品牌：Thermo Fisher

物种：人

宿主：其它

抗体亚型：其它

荧光染料：其它

灵敏度	0.12 ng/mL
检测范围	0.12-25 ng/mL
样本类型/体积	血清 50 μL 血浆 50 μL 上清液 50 μL
操作时间	1 hr 20 min
测试时间	4 hr 45 min
Homogenous (no wash)	No
批间变异系数（CV）	<12%
批内变异系数（CV）	<10%
仪器设备	Colorimetric Microplate Reader 酶标仪
规格	5 x 96 Tests
组份	- 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖
储存温度	2-8℃
Protein name	CLEC9A
Protein aliases	C-type lectin domain family 9 member A, C-type lectin domain family 9, member A, CD370, HEEE9341
物种（Tested）	人
试剂盒类型	Sandwich ELISA Kit
标记（染料）	HRP
检测抗体偶联物	Biotin
Gene aliases	CD370, CLEC9A, DNGR-1, DNGR1, UNQ9341, UNQ9341/PRO34046
Gene ID	(Human) 283420
Gene symbol	CLEC9A
UniProt ID	(Human) Q6UXN8

Human CLEC9A quantitates human CLEC9A in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CLEC9A.人CLEC9A定量检测血清，血浆，上清液中的人CLEC9A。该检测试剂盒将只识别天然和重组人CLEC9A。Target information 靶标信息CLEC9A is a group V CTLR (C-type lectin-like receptor) that functions as an activation receptor and is expressed on myeloid lineage cells. This protein is also expressed at the cell surface and acts as glycosylated dimers which mediate endocytosis, but not phagocytosis (Poulin LF et al, 2010). It facilitates antigen uptake and presentation, and may provide a suitable target for antibody-mediated antigen delivery. CLEC9A is important for conveying information from necrotic cells to T-cells and defines a pathway by which adaptive immune responses can be initiated in the absence of infection. It recruits Syk to mediate sensing of necrosis by the principal DC subset involved in regulating cross priming to cell-associated antigens. Signaling via this kinase occurs through a novel pathway involving CARD9 which induce a variety of cellular responses including the induction of cytokines (such as TNF, IL-6, IL-10, IL-23, and IL-2), the respiratory burst, and the production of Arachidonic acid. In addition, it also induces TH17 (T-helper type 17) adaptive responses in vivo. Expression of CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3+ DCs and on a small subset of CD14+ CD16- monocytes. CLEC9A serves as a new marker to distinguish subtypes of DCs.CLEC9A是V组CTLR（C型凝集素样受体），起激活受体的作用，并在髓系谱系细胞上表达。该蛋白还在细胞表面表达，并充当糖基化的二聚体，其介导内吞作用，而不是吞噬作用（Poulin LF et al，2010）。它促进抗原的摄取和呈递，并可以为抗体介导的抗原递送提供合适的靶标。 CLEC9A对于将信息从坏死细胞传递到T细胞非常重要，它定义了在没有感染的情况下可以启动适应性免疫应答的途径。它招募Syk通过参与调控与细胞相关抗原的交叉启动的主要DC子集来介导坏死的感知。通过这种激酶发出的信号是通过涉及CARD9的新型途径发生的，该途径诱导多种细胞应答，包括细胞因子（如TNF，IL-6，IL-10，IL-23和IL-2）的诱导，呼吸爆发，和花生四烯酸的生产。此外，它还可以在体内诱导TH17（17型T辅助）适应性反应。 CLEC9A的表达在外周血中高度受限，仅在BDCA3 + DC和一小部分CD14 + CD16-单核细胞中被检测到。 CLEC9A用作区分DC亚型的新标记。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。

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Human CLEC9A ELISA Kit ELISA试剂盒,Human CLEC9A ELISA Kit/人CLEC9A ELISA试剂盒

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