SIRT2 Recombinant Rabbit Monoclonal Antibody (SN70-04)

货号：MA5-32320

规格：100 µL

价格：4732

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Synthetic peptide within C-terminal human SIRT2

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

克隆号：SN70-04

荧光染料：Alexa Fluor 488

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:50-1:100(Flow) ;1:50-1:200(ICC);1:50-1:200(IF)

产品详细信息Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.靶标信息The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.

数据：

SIRT2 Antibody (MA5-32320) in ICCImmunocytochemical analysis of SIRT2 in PC-12 cells using a SIRT2 Monoclonal antibody (Product # MA5-32320) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. SIRT2 Antibody (MA5-32320) in FlowFlow Cytometric analysis of SIRT2 in Hela cells using a SIRT2 Monoclonal Antibody (Product # MA5-32320) at a dilution of 1:50, as seen in red compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.

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