Rabbit IL-17A ELISA Kit ELISA试剂盒,Rabbit IL-17A ELISA Kit/兔THE 17A ELISA试剂盒

2024-10-24

Rabbit IL-17A ELISA Kit/兔THE 17A ELISA试剂盒

货号:ER6RB,ER6RBX5

规格:96 Tests,5X96 Tests

价格:6641,29884

产品类型:Platinum ELISA

品牌:Thermo Fisher

物种:兔

宿主:其它

抗体亚型:其它

荧光染料:其它

灵敏度

0.2 ng/mL

检测范围0.2-50 ng/mL

样本类型/体积

血清 50 μL

血浆 50 μL

上清液 50 μL

操作时间

1 hr 20 min

测试时间

4 hr 45 min

Homogenous (no wash)

No

批间变异系数(CV)<12%
批内变异系数(CV)<10%

仪器设备

Colorimetric Microplate Reader 酶标仪

规格

5 x 96 Tests

组份

- 预包被96孔板

- 标准品

- 测定稀释浓缩液

- 生物素化检测抗体

- SAV-HRP

- 洗涤液

- 显色剂

- 终止液

- 胶板盖

储存温度

2-8℃

Protein nameIL-17A
Protein aliasesinterleukin 17A-like

物种(Tested)

试剂盒类型

Sandwich ELISA Kit

标记(染料)

HRP

检测抗体偶联物Biotin
Gene ID(Rabbit) 100339322
Gene symbolLOC100339322
Rabbit IL-17A quantitates rabbit IL-17A in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rabbit IL-17A.兔IL-17A定量测定血清,血浆,上清液中的兔IL-17A。该检测试剂盒将只识别天然和重组兔IL-17A。Target information 靶标信息Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).白介素-17A(IL-17A,CTLA-8)是CD4 + T细胞衍生的细胞因子,可促进细胞系中的炎症反应,并在类风湿性关节炎,哮喘,多发性硬化症,牛皮癣和移植排斥反应中升高。 IL-17A是一个32 kDa长的,二硫键连接的同型二聚体,由136个氨基酸组成,是六种蛋白质家族(IL-17A-17F)的成员,并通过IL-17受体(IL-17R / CDw217)。活化的外周血CD4 + T细胞产生高水平的IL-17A同型二聚体,并且IL-17A还增强人成纤维细胞中细胞内粘附分子1(ICAM-1)的表达。特别地,人IL-17A还刺激上皮,内皮或成纤维细胞分泌IL-6,IL-8,G-CSF和PGE2。在人IL-17A存在的情况下,成纤维细胞可以维持CD34 +造血祖细胞的增殖并诱导成熟为嗜中性粒细胞。小鼠,大鼠和人IL-17A可以诱导小鼠基质细胞分泌IL-6,这表明所有同源物都可以识别小鼠受体。 IL-17A调节NF-κB和丝裂原激活的蛋白激酶的活性,刺激IL-6和环氧合酶2(PTGS2 / COX-2)的表达,并增强一氧化氮(NO)的产生。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。

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