JMJD3 Polyclonal Antibody

货号：PA5-35012

规格：200 µL

价格：5548

产品类型：标签抗体

品牌：Thermo Fisher

抗原：KLH conjugated synthetic peptide between 1-30 amin

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：		用法：	1:10-1:50（ICC）；1:10-1:50（IF）；1:10-1:50（IHC(P)）；1:1000(WB)

产品详细信息This antibody is predicted to react with mouse based on sequence homology.靶标信息Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

数据：

JMJD3 Antibody (PA5-35012) in IFImmunofluorescent analysis of JMJD3 in Hela cells using a JMJD3 polyclonal antibody (Product # PA5-35012) followed by detection using a fluorescent conjugated secondary antibody (green). Nuclei were stained with Dapi (blue) and cytoplasmic actin was stained with a fluorescent phalloidin (red). JMJD3 Antibody (PA5-35012) in IHC (P)Immunohistochemistry analysis of JMJD3 in formalin-fixed, paraffin-embedded human brain tissue using a JMJD3 polyclonal antibody (Product # PA5-35012) followed by DAB staining. JMJD3 Antibody (PA5-35012) in WBWestern blot analysis of JMJD3 in Hela cell lysate (35 µg/lane) using a JMJD3 polyclonal antibody (Product # PA5-35012).

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