CD103 (Integrin alpha E) Monoclonal Antibody (Ber-ACT8), APC, eBioscience
货号:17-1037-42
规格:100 Tests
市场价格:2677
产品类型:流式抗体
品牌:eBioscience
抗原:CD103
物种:人
宿主:小鼠
抗体亚型:IgG1, kappa
克隆号:Ber-ACT8
荧光染料:APC
类型: | 一抗 | 同型对照: | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience |
浓度: | 5 µL/Test | 用法: | 5 µL (0.06 µg)/test(Flow) |
产品详细信息Description: The Ber-ACT8 monoclonal antibody reacts with human CD103, the alphaE integrin. CD103 non-covalently associates with integrin beta7. CD103 is expressed mainly on intraepithelial lymphocytes and a small subset of peripheral lymphocytes. CD103 is also expressed by hairy cell leukemia (HCL) and by some chronic B cell lymphocytic leukemias. I{In vitroI} stimulation of human T cells with mitogens induces upregulation of CD103. Epithelial cell antigen (E-cadherin) binds to CD103 and mediates homing of lymphocytes to the intestinal epithelium. Cross-blocking studies suggest that antibody clones B-Ly7 and Ber-ACT8 see different epitopes.Applications Reported: This Ber-ACT8 antibody has been reported for use in flow cytometric analysis.Applications Tested: This Ber-ACT8 antibody has been pre-titrated and tested by flow cytometric analysis of stimulated human peripheral blood cells. This can be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells. In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain. CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. CD103 is part of the integrin family which are heterodimeric integral membrane proteinscomposed of an alpha chain and a beta chain. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.仅用于科研。不用于诊断过程。
数据 |
CD103 (Integrin alpha E) Antibody (17-1037-42) in FlowStaining of 3-day PHA-stimulated normal human peripheral blood cells with Anti-Human CD8a PerCP-eFluor® 710 (Product # 46-0087-42) and Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (left) or Anti-Human CD103 (Integrin alpha E) APC (right). Total viable cells were used for analysis. |
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