CD38 Monoclonal Antibody (38C03 (SPC32))

货号：MA514413

规格：500 µL

价格：4733

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG1

克隆号：38C03 (SPC32)

荧光染料：其它

类型:	单抗	同型对照：
浓度：		用法：	1:50-1:200(WB)；1:50-1:100(IHC (P))；1:2(Flow)

产品详细信息MA5-14413 targets CD38 in WB, FACS and IHC (P) applications and shows reactivity with Human and Mouse samples. This antibody is not suitable for Jurkat cell lysates or mouse thymus tissues in Western blot analysis.The MA5-14413 immunogen is recombinant protein encoding the extracellular domain of human CD38.靶标信息CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

数据

CD38 Antibody (MA5-14413) in IHCFormalin-fixed, paraffin-embedded human tonsil stained with CD38 using peroxidase-conjugate and AEC chromogen. Note membrane staining of lymphocytes.

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参考文献：

1.The Biochemical journalChannelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform."MA5-14413 was used in western blot to generate enzymatic data supporting the presence in skeletal muscle of an ADP-ribosyl cyclase isoform distinct from CD38"2.Arthritis research & therapyUpregulation of tumor necrosis factor receptor-associated factor 6 correlated with synovitis severity in rheumatoid arthritis."MA5-14413 was used in Immunohistochemistry to investigate tumour necrosis factor receptor-associated factor 6 expression in the rheumatoid arthritis synovium, and its correlation with histological synovitis severity and radiological joint destruction in rheumatoid arthritis."3.Journal of clinical pathologyAnalysis of the IgVH genes in T cell-mediated and antibody-mediated rejection of the kidney graft."MA5-14413 was used in immunohistochemistry to investigate the role of IgVH genes in host-graft rejection in renal transplants"4.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieDiagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases."MA5-14413 was used in immunohistochemistry to investigate the diagnosis of lymphoid neoplasmas through bone marrow trephine biopsies"5.Arthritis research & therapyPlasma cells within granulomatous inflammation display signs pointing to autoreactivity and destruction in granulomatosis with polyangiitis."MA5-14413 was used in immunohistochemistry - paraffin section to describe the features of plasma cells in patients with granulomatosis with polyangiitis"

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